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beta1-Adrenoceptor gene polymorphism predicts long-term changes in body weight
Y Linné1, I Dahlman, J Hoffstedt
1Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.
International Journal of Obesity (2005)
|February 3, 2005
Summary
Genetic variations in the beta1-adrenoceptor gene influence long-term weight gain. Specific gene variants are linked to increased body mass index and overweight risk in women over time.
Area of Science:
- Genetics and Molecular Biology
- Human Physiology
- Obesity Research
Background:
- Long-term weight change determinants are largely unknown.
- The beta1-adrenoceptor gene has two functional single nucleotide polymorphisms (SNPs): Ser49Gly and Gly389Arg.
Purpose of the Study:
- To investigate the influence of beta1-adrenoceptor gene SNPs (Ser49Gly and Gly389Arg) on short- and long-term body mass index (BMI) changes.
- To determine the association between these SNPs and the incidence of overweight in women.
Main Methods:
- A population-based cohort of 761 women was studied.
- Participants were examined during pregnancy and 15 years later.
- Genotyping for Ser49Gly and Gly389Arg SNPs was performed.
Main Results:
- No genotype effect on BMI was observed at baseline.
- After 15 years, women with the Gly49-genotype had higher BMI and greater BMI increase compared to Ser49-women.
- The Gly49-genotype was associated with an increased odds ratio for being overweight after 15 years.
- A significant genotype-genotype interaction was found for the Gly49-Gly389 combination, leading to greater BMI increase.
Conclusions:
- Polymorphisms in the beta1-adrenoceptor gene significantly influence long-term weight gain in women.
- These genetic variations are associated with the incidence of adult-onset overweight.