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Low plasma growth hormone binding protein in IDDM
M Mercado1, M E Molitch, G Baumann
1Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
Diabetes
|May 1, 1992
Summary
Poorly controlled insulin-dependent diabetes mellitus (IDDM) is linked to growth hormone (GH) resistance. This study found lower GH-binding protein (GHBP) levels in IDDM patients, suggesting reduced GH receptor levels contribute to GH resistance.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Molecular Biology
Background:
- Poorly controlled insulin-dependent diabetes mellitus (IDDM) is associated with elevated growth hormone (GH) and low insulin-like growth factor I (IGF-I), indicating GH resistance.
- The precise mechanism of GH resistance in IDDM, particularly the role of GH receptors, remains unclear.
Purpose of the Study:
- To investigate the potential involvement of GH receptors in GH resistance in IDDM.
- To measure plasma GH-binding protein (GHBP) levels as a marker for GH receptor levels in patients with IDDM, non-insulin-dependent diabetes (NIDDM), and healthy controls.
Main Methods:
- Plasma GHBP levels were measured in patients with IDDM, NIDDM, and nondiabetic control subjects.
- Basal plasma GH and IGF-I levels were also assessed.
- Statistical analyses were performed to compare groups and examine correlations between GHBP, GH, IGF-I, HbA1, and diabetes duration.
Main Results:
- Patients with IDDM exhibited significantly lower plasma GHBP levels compared to NIDDM patients and control subjects.
- Elevated basal plasma GH levels were observed in IDDM patients.
- No significant difference in IGF-I levels was found between IDDM and NIDDM patients. Correlations between GHBP and IGF-I differed between IDDM and NIDDM groups.
Conclusions:
- IDDM is associated with reduced GHBP levels, suggesting a decrease in GH receptor levels.
- This reduction in GH receptor levels may contribute to the GH resistance observed in IDDM.