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Related Concept Videos

Esophagus01:24

Esophagus

The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...

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Related Experiment Video

Updated: Jul 22, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

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Comparative studies of esophageal function in systemic sclerosis.

H A Klein1, A Wald, T O Graham

  • 1Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania.

Gastroenterology
|May 1, 1992
PubMed
Summary

This study found that esophageal manometry, cine-esophagography, and scintigraphy are equally effective in diagnosing esophageal dysfunction in systemic sclerosis patients. These methods accurately assess esophageal motor function severity.

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Area of Science:

  • Gastroenterology
  • Rheumatology
  • Medical Imaging

Background:

  • Systemic sclerosis frequently causes esophageal dysfunction, impacting patient quality of life.
  • Accurate assessment of esophageal motor function is crucial for managing systemic sclerosis patients.

Purpose of the Study:

  • To prospectively compare three diagnostic modalities for esophageal dysfunction in systemic sclerosis: manometry, cine-esophagography, and scintigraphy.
  • To evaluate the correlation between these methods and their ability to discriminate between normal and abnormal esophageal motor function.

Main Methods:

  • Seventeen systemic sclerosis patients underwent esophageal manometry, cine-esophagography, and esophageal transit scintigraphy.
  • Key parameters measured included pressure amplitudes, peristaltic wave percentages, sphincter pressure, contrast residual, and tracer quantification.

Main Results:

  • Highly significant correlations were observed between scintigraphy, cine-esophagography, and manometric amplitude, excluding lower esophageal sphincter pressure.
  • Scintigraphy and cine-esophagography demonstrated comparable diagnostic discrimination for esophageal motor abnormalities.
  • Patient symptoms and Raynaud's phenomenon induction did not significantly correlate with quantitative esophageal function parameters.

Conclusions:

  • Esophageal manometry, cine-esophagography, and scintigraphy are approximately equivalent in detecting and quantifying esophageal dysmotility in systemic sclerosis.
  • These modalities offer reliable, comparable assessments of esophageal motor function severity in this patient population.