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Updated: Aug 19, 2026

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
Published on: January 19, 2024
[The connection between vitamin and iron status indexes of school-age children]
Insights
Vitamin E deficiency is common in anemic children, impacting iron levels and red blood cell health. Supplementation with vitamin E and B vitamins may aid in treating certain anemias.
Area of Science:
- Pediatric Nutrition
- Hematology
- Biochemistry
Background:
- Vitamin E deficiency is prevalent in anemic children.
- Anemia is linked to decreased hemoglobin and erythrocyte parameters.
- Carotenoid and vitamin B2 sufficiency does not preclude vitamin E deficiency.
Purpose of the Study:
- To analyze vitamin and iron status in children with carotenoid and vitamin B2 sufficiency.
- To investigate the relationship between vitamin E levels and anemia indicators.
- To explore the role of vitamin E in iron metabolism and anemia etiology.
Main Methods:
- Analysis of vitamin and iron indexes in 95 children.
- Comparison of vitamin E status between anemic and healthy children.
- Correlation analysis between serum vitamin E levels and iron indicators (hemoglobin, ferritin).
Main Results:
- Vitamin E deficit occurred 2x more often in anemic children.
- Reduced hemoglobin and erythrocyte indices were 1.7-2.4x more frequent in vitamin E deficient children.
- A positive linear correlation was found between iron indexes and serum vitamin E levels, especially in iron deficiency anemia.
Conclusions:
- Vitamin E plays a significant role in the body's iron supply.
- Multi-deficient anemia, not solely iron deficit, is present in some children.
- Vitamin E and B group vitamin deficiencies are frequent, suggesting their inclusion in iron deficiency anemia therapy.
Abstract:
The analysis of vitamin and iron indexes of 95 children sufficiently supplied with vitamin C and vitamin B2 and carotenoids deficiency has been carried out. Vitamin E deficit takes place among anemic children (with decreased hemoglobin blood level) 2 fold more often than among healthy children. From another side, decreased hemoglobin blood level, erythrocyte quantity and erythrocyte indexes have been determined 1.7-2.4 fold more often in insufficiently supplied with vitamin E children. Tocopherols serum level had tendency to the decrease and vitamin E deficit took place 2 fold more frequently in children suffering from iron deficiency anemia that is with decreased hemoglobin and serum ferritin concentrations. Marked positive linear correlation between these iron indexes and vitamin E serum level has been revealed. These results give evidence concerning significant role of this vitamin in the body iron supplying. The results obtained give evidence for multi-deficient anemia presence among children, which are not always caused by iron deficit. High frequency of vitamin E and B group vitamins deficiency proves expediency of these vitamins inclusion in complex therapy of iron deficiency.
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