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Updated: Aug 14, 2026

Sample Preparation for Single Virion Atomic Force Microscopy and Super-resolution Fluorescence Imaging
Published on: January 3, 2014
Irreversible and reversible adhesion between virus particles and hydrolyzing-precipitating aluminium: a function of
T Matsushita1, Y Matsui, T Inoue
1Department of Civil Engineering, Gifu University, Gifu 501-1193, Japan. taku_m@cc.gifu-u.ac.jp
Abstract:
The infectivity of viruses (Qbeta, MS2, T4, and P1) after dosing virus-contaminated water with 4 types of aluminium coagulant was investigated. The concentrations of infectious viruses were determined after dissolving aluminium hydroxide flocs in alkaline solution. The concentration of infectious viruses did not recover to the initial value after a short floc-dissolution time (5 s). Although the infectious virus concentration increased as the floc-dissolution time was extended to 5 h, it did not recover fully. Irreversible adhesion between virus particles and aluminium coagulant is responsible for the insufficient recovery. We interpret this phenomenon as a virucidal activity of the aluminium coagulant. All tested aluminium coagulants (PACl, alum, and reagent grade aluminium chloride and aluminium sulfate) inactivated all types of viruses tested. PACl had the highest virucidal activity. The virucidal activity of aluminium coagulants was lower in river water, presumably owing to the presence of natural organic matter.
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