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[Renal neoplasms in children].

Krystyna Sawicz-Birkowska1, Jerzy Czernik, Maciej Bagłaj

  • 1Klinika Chirurgii i Urologii Dzieciecej Akademii Medycznej we Wrocławiu.

Przeglad Lekarski
|February 3, 2005
PubMed
Summary

Neoadjuvant chemotherapy significantly improved outcomes for pediatric kidney tumors, including nephroblastoma and non-Wilms tumors. This approach facilitated surgery and enhanced overall survival rates in Polish children.

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Area of Science:

  • Pediatric Oncology
  • Nephrology
  • Clinical Research

Context:

  • Nephroblastoma is the most common pediatric kidney tumor in Poland.
  • A significant number of children present with various stages of renal tumors.
  • Previous treatment protocols showed varying success rates.

Purpose:

  • To evaluate the clinical outcomes of 533 children diagnosed with renal tumors between 1993 and 2002.
  • To assess the efficacy of neoadjuvant chemotherapy in treating pediatric nephroblastoma and other renal tumors.
  • To analyze survival rates based on tumor stage and treatment response.

Summary:

  • The study included 500 cases of nephroblastoma and 33 non-Wilms renal tumors.
  • Neoadjuvant chemotherapy was administered to 93.8% of patients, followed by surgery.

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  • Overall 5-year survival for nephroblastoma ranged from 58% (Stage V) to 96.8% (Stage II), with an overall survival of 78.7% for all patients.

    • Impact:

    • Neoadjuvant chemotherapy led to tumor shrinkage, enabling complete surgical nephrectomy.
    • Improved outcomes were observed for both nephroblastoma and non-Wilms renal tumors.
    • This study highlights the benefits of standardized chemotherapy protocols in pediatric renal oncology.