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Related Experiment Video

Updated: May 11, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

Erythromycin and the gut.

S M Catnach¹, P D Fairclough

¹Department of Gastroenterology, St Bartholomew's Hospital, London.

|March 1, 1992

Summary

This summary is machine-generated.

Erythromycin

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Last Updated: May 11, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

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Published on: January 13, 2013

Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation

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Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Area of Science:

Gastroenterology
Pharmacology

Background:

Gastrointestinal side effects of erythromycin stem from its prokinetic action.
This action is linked to stimulating the gut's motilin receptors.

Purpose of the Study:

To explore the clinical utility of erythromycin's prokinetic effects.
To investigate potential therapeutic uses in gastrointestinal hypomotility disorders.

Main Methods:

Review of erythromycin's mechanism of action.
Discussion of potential applications in diabetic gastroparesis and intestinal pseudo-obstruction.

Main Results:

Erythromycin's motilin receptor activity drives its gastrointestinal effects.
Potential therapeutic benefits for hypomotility disorders exist but require further research.

Conclusions:

Erythromycin's prokinetic properties show promise for treating gastrointestinal hypomotility.
Development of non-antibiotic 'motilides' offers new therapeutic options for prokinetic agents.