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QT interval prolongation in diphenhydramine toxicity
International Journal of Cardiology
|February 3, 2005
Summary
Diphenhydramine overdose can cause serious heart problems, including dangerous rhythms and prolonged QT intervals. Prompt medical treatment can reverse these effects, highlighting the importance of timely intervention for poisoning.
Area of Science:
- Toxicology
- Cardiology
- Emergency Medicine
Background:
- Diphenhydramine overdose is a common cause of acute poisoning.
- Overdoses can lead to central nervous system, anticholinergic, and cardiovascular symptoms.
Observation:
- An adolescent male presented with unresponsiveness and seizure-like activity following moderate diphenhydramine ingestion.
- Electrocardiogram revealed wide complex tachycardia with a right bundle branch block and QT interval prolongation.
Findings:
- Massive diphenhydramine ingestions are linked to myocardial depression and ECG changes like QRS widening and QT prolongation.
- The observed ECG abnormalities in this case resolved with treatment.
Implications:
- Diphenhydramine overdose can occasionally cause QT interval prolongation, a significant cardiovascular risk.
- This case underscores the potential for significant cardiac manifestations in diphenhydramine toxicity.
- Recognition and management of cardiac symptoms are crucial in diphenhydramine overdose cases.