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Updated: Aug 19, 2026
Elevated Plus Maze for Mice
Published on: December 22, 2008
Genetic differences in the elevated plus-maze persist after first exposure of inbred rats to the test apparatus
G S Izídio1, L Spricigo, A Ramos
1Laboratório de Genética do Comportamento, Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88.040-900 Florianópolis, SC, Brazil.
Abstract:
The elevated plus-maze (EPM) is an anxiety model thought to assess different types of emotional states depending on whether or not the animals have been previously exposed to the test apparatus. Accordingly, benzodiazepine-treated rodents generally differ from controls in the first but not in the second EPM trial. Inbred Lewis and SHR rats of both sexes (N=10) were submitted twice (test and retest) to the EPM with a 24 h interval between trials. Overall strain differences (Lewis
