Related Experiment Video
Updated: Aug 19, 2026

08:40
An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions
Published on: March 14, 2016
Identification of nonpeptidic small-molecule inhibitors of interleukin-2
Nathan D Waal1, Wenjin Yang, Johan D Oslob
1Sunesis Pharmaceuticals, Inc., 341 Oyster Point Boulevard, South San Francisco, CA 94080, USA. nwaal@sunesis.com
Bioorganic & Medicinal Chemistry Letters
|February 3, 2005
Abstract:
The identification, design, and synthesis of a series of novel sulfamide- and urea-based small-molecule antagonists of the protein-protein interaction IL-2/IL-2Ralpha are described. Installation of a furan carboxylic acid fragment onto a low-micromolar sulfamide resulted in a 23-fold improvement in activity, providing a sub-micromolar, nonpeptidic IL-2 inhibitor (IC(50)=0.60 microM).

