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[24-hour blood pressure decrease with nifedipine with a new galenic action].

G Bühler1, J R Rosenthal, J Santak

  • 1Abteilung Psychosomatik, Universität Ulm.

Fortschritte Der Medizin
|February 10, 1992
PubMed
Summary
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Slow-release nifedipine effectively lowers blood pressure for 24 hours in patients with essential hypertension. Evening administration demonstrated a favorable impact on morning blood pressure, with minimal side effects observed.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Essential hypertension remains a significant global health concern, necessitating effective long-term blood pressure management strategies.
  • Current treatments often face challenges with adherence and sustained efficacy throughout the day.

Purpose of the Study:

  • To evaluate the 24-hour blood pressure-lowering efficacy of a slow-release nifedipine formulation.
  • To assess the safety and tolerability of this slow-release nifedipine preparation in hypertensive patients.

Main Methods:

  • A single-blind, randomized, placebo-controlled, crossover study involving 18 inpatients with essential hypertension (blood pressure > 160/95 mmHg).
  • Participants received a single 60 mg slow-release nifedipine tablet (Aprical long 60 mg) or placebo daily at 1800 hours.
  • Blood pressure and pulse were measured at multiple intervals up to 24 hours post-administration.

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Main Results:

  • Slow-release nifedipine significantly reduced systolic blood pressure by an average of 20 mmHg and diastolic blood pressure by 14 mmHg, sustained for 18-24 hours.
  • The active treatment group showed a 40% (systolic) and 49% (diastolic) greater likelihood of achieving target blood pressure (< 160/95 mmHg) compared to placebo.
  • Fifteen patients maintained blood pressure within the target range for the full 24-hour period, with rare occurrences of side effects like headache and flushing.

Conclusions:

  • Slow-release nifedipine (60 mg) provides effective and sustained 24-hour blood pressure control in essential hypertension.
  • Evening administration appears beneficial for managing morning blood pressure surges, offering a well-tolerated therapeutic option.