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Updated: Jul 15, 2026
13:44
Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
Published on: August 30, 2013
Rationale for annual screening mammography for women ages 40-49 years
S A Feig1, D B Kopans, E A Sickles
1Department of Radiology, Breast Imaging Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107-5563, USA.
Breast Disease
|February 3, 2005
Summary
Mammograms for women aged 40-49 significantly reduce breast cancer mortality. Studies show benefits outweigh risks, supporting screening mammography starting at age 40.
Area of Science:
- Oncology
- Preventive Medicine
- Radiology
Background:
- Mammographic screening is a key tool in breast cancer detection.
- Evidence for screening benefits in women aged 40-49 has been evolving.
Purpose of the Study:
- To summarize the evidence supporting mammographic screening for women aged 40-49.
- To evaluate the mortality reduction associated with screening mammography in this age group.
Main Methods:
- Review of randomized controlled trials (RCTs) from Gothenburg and Malmo, Sweden.
- Meta-analysis of five Swedish screening trials.
- Assessment of benefits versus risks of mammographic screening.
Main Results:
- RCTs demonstrated statistically significant breast cancer mortality reductions (36% in Gothenburg, 45% in Malmo).
- A meta-analysis of Swedish trials showed a 29% mortality reduction for women aged 40-49.
- Benefits of screening are substantial, with relatively small and acceptable risks.
Conclusions:
- Mammographic screening beginning at age 40 is supported by robust evidence.
- Recommendations from major health organizations (American Cancer Society, National Cancer Institute) align with these findings.
- Annual screening may yield even greater mortality reductions.
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