Percutaneous breast biopsy for nonpalpable lesions

Increasingly, biopsies for suspected breast abnormalities are conducted by percutaneous needle extraction of core samples rather than by standard surgical excision or fine-needle aspiration (FNA) of cellular material. Core-needle biopsies are highly accurate and have many advantages over surgical excisions, including reduction of the morbidity and cost of breast disease diagnosis. Limitations include differentiating atypical ductal hyperplasia from ductal carcinoma in situ. Equipment and technique for stereotactic and ultrasound-guided core breast biopsy are discussed. Appropriate indications for core-needle biopsy, excisional biopsy after needle localization, and FNA are provided. Appropriate management after core-needle biopsy includes the establishment of concordance of histologic results with the level of suspicion of the mammographic findings to prevent false-negative core biopsies. A recommendation for return to regular mammographic screening, short-interval (6-month) mammographic follow-up, or repeat core or surgical appearance depends on this correlation.