Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enteroaggregative Escherichia coli pathogenesis.

James P Nataro1

  • 1University of Maryland, School of Medicine, Baltimore, MD, USA. jnataro@medicine.umaryland.edu

Current Opinion in Gastroenterology
|February 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to 'The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of EED' [The American Journal of Clinical Nutrition. 2024; 120S1: S4-S14].

The American journal of clinical nutrition·2026
Same author

Whole-genome analysis of rotavirus G1P[8] and other Wa-like strains in Mozambican children: evidence of genetic variations of pre-vaccine G1P[8] strains from Manhiça, Mozambique.

Microbial genomics·2025
Same author

CD45-mediated apoptosis and IL-2 receptor downregulation by serine proteases secreted from diarrheagenic bacteria.

bioRxiv : the preprint server for biology·2025
Same author

Genomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique.

Scientific reports·2024
Same author

The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction.

The American journal of clinical nutrition·2024
Same author

Identification of Enteric Pathogen Reservoirs and Transmission Pathways Associated with Short Childhood Stature in the Kolkata Indian Site of the Global Enteric Multicenter Study.

Nutrients·2024

Enteroaggregative Escherichia coli (EAEC) causes diarrhea globally. Identifying the AggR regulator and its related genes helps detect typical EAEC strains, crucial for clinical and epidemiological studies.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Enteroaggregative Escherichia coli (EAEC) is a significant diarrheal pathogen.
  • EAEC infections are relevant in both traveler's diarrhea and endemic settings worldwide.
  • Understanding EAEC pathogenesis is crucial for clinical and epidemiological insights.

Purpose of the Study:

  • To review current understanding of EAEC pathogenesis.
  • To highlight the role of the AggR regulator in EAEC virulence.
  • To emphasize the importance of identifying typical EAEC strains.

Main Methods:

  • Review of existing literature on EAEC pathogenesis.
  • Analysis of virulence factors controlled by the AggR regulator.
  • Discussion of diagnostic and epidemiological implications.

Related Experiment Videos

Main Results:

  • EAEC pathogenesis involves intestinal colonization, enterotoxin/cytotoxin production, and mucosal inflammation.
  • The global regulator AggR controls key EAEC virulence factors, including adherence factors and a large chromosomal gene cluster.
  • AggR and its regulon members are potential markers for identifying pathogenic EAEC strains.

Conclusions:

  • Identification of AggR or its regulon members can define typical EAEC strains.
  • Detection of typical EAEC should be incorporated into clinical and epidemiological investigations.
  • Advances in understanding EAEC pathogenesis inform disease control strategies.