Related Experiment Videos
Rotavirus disease and its prevention
Marc-Alain Widdowson1, Joseph S Bresee, Jon R Gentsch
1Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. zux5@cdc.gov
Current Opinion in Gastroenterology
|February 3, 2005
Summary
Rotavirus infection causes severe childhood gastroenteritis globally. New vaccines are being developed to address the ongoing disease burden and challenges from earlier vaccine introductions.
Area of Science:
- Virology
- Immunology
- Pediatrics
Background:
- Rotavirus is a leading cause of severe gastroenteritis in young children worldwide.
- The first rotavirus vaccine (RRV-TV) was withdrawn due to intussusception concerns, impacting vaccine development.
- Rotavirus infection can present with extraintestinal manifestations, including viremia.
Purpose of the Study:
- To review current knowledge on rotavirus infection, including clinical presentation, pathogenesis, and global disease burden.
- To discuss the challenges and opportunities in developing next-generation rotavirus vaccines.
- To highlight ongoing efforts in rotavirus vaccine development and introduction.
Main Methods:
- Review of recent studies on rotavirus infection and vaccine development.
- Analysis of global disease burden estimates and mortality data.
- Examination of clinical trial data for new rotavirus vaccines.
Main Results:
- Rotavirus infection has extraintestinal manifestations, such as viremia.
- Global rotavirus diarrhea mortality has not declined, and its proportion in hospitalizations has increased.
- New rotavirus vaccines are in late development stages, with some licensed or nearing licensure.
Conclusions:
- The significant global burden of rotavirus diarrhea necessitates continued vaccine development.
- Diverse approaches are being pursued to create effective and safe rotavirus vaccines.
- Ongoing research and development aim to provide widespread access to next-generation rotavirus vaccines.