Related Experiment Video
Updated: Aug 19, 2026
Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
[Diffuse diabetic macular edema and vitreoretinal interface pathology: a study of seven cases (ten eyes)]
F Basteau1, B Mortemousque, F Aouizerate
1Clinique Ophtalmologique, Hôpital Pellegrin, place Amélie Raba Léon, 33076 Bordeaux cedex, France.
Purpose:
Diffuse diabetic macular edema (DDME) is a serious complication, only partially understood. In this study, we have attempted to find a relation between DDME and a pathologic vitreo-retinal interface (VRI).
Patients:
We examined ten eyes using biomicroscopy, fluorescein angiography, B mode echography and for five of these eyes, OCT. We found that DDME and pathological VRI are indeed associated.
Discussion:
We hypothesize that structural and biochemical changes of the vitreoretinal interface are closely related to the progression of DDME. We support this hypothesis with anatomical, epidemiological, physiopathological, clinical and paraclinical arguments.
Conclusion:
Diffuse diabetic macular edema appears to be mediated by vitreomacular traction caused by structural and biochemical changes of the vitreoretinal interface. The pathological inner limiting membrane (ILM) seems to be a risk factor in DDME development. During pars plano vitrectomy, the additional peeling of the ILM could improve the resolution of the macular edema.
