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[Increase in C-reactive protein plasma levels during diabetes in infants and young adults]

J Coulon1, D Willems, H Dorchy

  • 1Clinique de diabétologie, Hôpital universitaire des Enfants Reine Fabiola, Bruxelles, Belgique.

Presse Medicale (Paris, France : 1983)
|February 3, 2005
PubMed

Insights

High sensitivity C-reactive protein (hs CRP) levels are elevated in young type 1 diabetic patients, indicating increased inflammation. Elevated hs CRP is linked to blood lipids and may predict subclinical complications.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Biochemistry
  • Inflammation Research

Background:

  • Type 1 diabetes (T1D) is a chronic condition requiring ongoing management.
  • Subclinical complications can develop early in T1D, necessitating sensitive detection methods.
  • Inflammation plays a role in the pathogenesis of diabetic complications.

Purpose of the Study:

  • To assess high sensitivity C-reactive protein (hs CRP) levels in young patients with T1D.
  • To explore the association of hs CRP with metabolic control (HbA1c), lipids, and subclinical complications.
  • To evaluate hs CRP as a potential biomarker for T1D complications.

Main Methods:

  • hs CRP, HbA1c, and lipid profiles were measured in 126 T1D patients and 52 controls.
  • Patients were categorized based on the presence or absence of subclinical complications (retinopathy, nephropathy, neuropathy).
  • Statistical analyses were performed to determine correlations and group differences.

Main Results:

  • hs CRP levels were significantly higher in T1D patients compared to controls (2.6+/-4mg/L vs 0.7+/-0.7mg/L; p<0.001).
  • Elevated hs CRP correlated with total cholesterol, LDL cholesterol, and cholesterol/HDL ratio.
  • hs CRP showed correlations with age and diabetes duration in patients without complications.

Conclusions:

  • hs CRP levels are significantly elevated in young T1D patients, even without complications.
  • hs CRP concentrations increase with the presence of subclinical complications.
  • hs CRP may serve as a valuable indicator for the risk of developing complications in T1D.
Abstract

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