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Synthesis and screening of a rationally designed combinatorial library of affinity ligands mimicking protein L from

A Cecília A Roque1, M Angela Taipa, Christopher R Lowe

  • 1Centro de Engenharia Biológica e Química, Instituto Superior Técnico, Lisboa, Portugal.

Journal of Molecular Recognition : JMR
|February 3, 2005
PubMed

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Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...