Related Experiment Video
Updated: Aug 1, 2026
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
Published on: February 28, 2021
Chronic pancreatitis--from losing heart to acting smart!
W T Knoefel1, S B Hosch, M Peiper
1Department of Surgery, University Hospital Duesseldorf, Duesseldorf, Germany. knoefel@uni-duesseldorf.de
Background:
Chronic pancreatitis is a progressive disease which complications lead to increased morbidity and social and professional problems.
Material And Methods:
The authors analysed the current treatment options for chronic pancreatitis and compared it to the former treatment options.
Results:
Historically surgical treatment options of chronic pancreatitis were associated with a high complication rate due to pancreatitic surgery. Furthermore, inadequate assessment of outcome lead to the treatment approach of watchful waiting and endoscopic interventions. Improving experiences with pancreatic surgery (high volume, combination of resection and drainage, e.g., duodenum-preserving pancreatic head resection) in some centers combined to modern evaluation methods revealed a low mortality (<5%), acceptable perioperative morbidity (15-20%), low reoperation rate (10%) and in 80% of the patients complete freedom of pain.
Conclusion:
A combination of drainage and resection tailored to the patient's need and performed early before developing endocrine insufficiency, seems to be the best medical care currently available to patients suffering from chronic pancreatitis.
Related Concept Videos
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:21Acute Pancreatitis II: Pathophysiology
01:25Chronic Pancreatitis I: Introduction
01:21Chronic Pancreatitis II: Pathophysiology