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Updated: Aug 19, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

[Cell death signalling: recent advances and therapeutic application]

Evelyne Ségal-Bendirdjian1, Charles Dudognon, Julie Mathieu

  • 1Inserm U496/685, Hôpital Saint-Louis, Centre G. Hayem, 1, avenue Claude Vellefaux, 75010 Paris.

Bulletin Du Cancer
|February 4, 2005
PubMed

Insights

Targeting apoptosis is key for cancer treatment due to its role in tumor growth and chemoresistance. New insights into cell death pathways offer novel strategies for drug development and effective cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Death Research

Context:

  • Apoptosis (programmed cell death) is frequently inactivated in tumors, promoting cancer development and treatment resistance.
  • Tumorigenesis and chemotherapy resistance are linked to the dysregulation of apoptotic pathways.
  • Emerging evidence suggests alternative cell death signaling pathways are crucial in cancer.

Purpose:

  • To review current understanding of apoptosis and alternative cell death pathways in cancer.
  • To explore the complexity of molecular events regulating cell death.
  • To identify how this knowledge can inform new cancer therapies.

Summary:

  • Apoptosis inactivation is a hallmark of cancer, contributing to carcinogenesis and therapeutic resistance.
  • Cancer cell death regulation is more complex than previously understood, involving alternative pathways.
  • Understanding these molecular pathways is vital for developing novel, targeted cancer treatments.

Impact:

  • Provides a foundation for pathway-based rational cancer therapy.
  • Highlights opportunities for innovative drug development targeting cell death mechanisms.
  • Aims to translate molecular insights into more effective clinical treatments for cancer.

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