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Interaction between vascular dysfunction and cardiac mass increases the risk of cardiovascular outcomes in essential

Angela Sciacqua1, Angela Scozzafava, Arturo Pujia

  • 1Internal Medicine and Cardiovascular Diseases Unit, Department of Experimental and Clinical Medicine G. Salvatore, University Magna Graecia of Catanzaro, Italy.

European Heart Journal
|February 4, 2005
PubMed

Insights

Hypertension patients with both endothelial dysfunction and increased left ventricular mass face a significantly higher risk of cardiovascular events. This study highlights the combined prognostic impact of these two factors.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Endothelial dysfunction and left ventricular mass (LVM) are known cardiovascular risk factors.
  • Their combined prognostic impact in hypertensive patients requires further investigation.

Purpose of the Study:

  • To assess the additive prognostic value of forearm endothelial dysfunction and LVM for predicting future cardiovascular events in hypertensive individuals.

Main Methods:

  • 324 never-treated hypertensive outpatients were enrolled.
  • Forearm endothelial function (acetylcholine-stimulated forearm blood flow) and echocardiographic LVM were measured.
  • Patients were stratified into tertiles based on endothelial function and LVM indexed by body surface area (LVMI).

Main Results:

  • A significant inverse relationship was observed between forearm blood flow and cardiovascular event rates.
  • A significant positive relationship was found between LVMI and cardiovascular event rates.
  • A significant interaction between endothelial function and LVMI was documented, with the highest risk observed in patients with low forearm blood flow and high LVMI (11.4% event rate).

Conclusions:

  • The co-existence of left ventricular hypertrophy (LVH) and endothelial dysfunction significantly elevates the risk of subsequent cardiovascular events in hypertensive patients.
  • This study provides novel evidence for the combined prognostic significance of these two markers.
Abstract

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