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Adenosine infusion and periodic breathing during sleep
1Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 1, 1992
Summary
Adenosine infusion increases ventilation and causes periodic breathing during sleep in healthy individuals. This sleep-disordered breathing was not predicted by baseline ventilatory responses to carbon dioxide.
Area of Science:
- Respiratory Physiology
- Sleep Medicine
Background:
- Adenosine administration may influence ventilation and the ventilatory response to carbon dioxide (HCVR).
- Higher HCVR has been hypothesized to correlate with increased susceptibility to periodic breathing during sleep.
Purpose of the Study:
- To investigate the effects of adenosine infusion on ventilation and ventilatory control during sleep.
- To determine if adenosine induces periodic breathing in healthy subjects and if baseline HCVR predicts this phenomenon.
Main Methods:
- Seven healthy subjects underwent continuous sleep monitoring during intravenous adenosine infusion (80 µg·kg⁻¹·min⁻¹).
- Ventilation (VI), end-tidal CO2, and ventilatory patterns were measured before and during adenosine infusion.
- The relationship between baseline HCVR and periodic breathing characteristics was analyzed.
Main Results:
- Adenosine significantly increased mean sleeping ventilation (VI) and tended to decrease end-tidal CO2.
- Periodic breathing developed in six of seven subjects during adenosine infusion.
- The amplitude and period length of periodic breathing varied and were not predicted by baseline HCVR.
Conclusions:
- Intravenous adenosine increases ventilation and frequently induces periodic breathing during sleep in healthy individuals.
- Adenosine infusion complicates the assessment of ventilatory control during sleep due to induced periodic breathing and arousals.