Neurohumoral control of exocrine pancreatic secretion

Advancing knowledge about normal physiology of the exocrine pancreas is essential for investigations into the mechanisms of disorders of the pancreas. To this end, reports published during the past year give further insights into the complexity of the hormonal and neural interactions and processes involved in exocrine pancreatic physiology.

Key findings include demonstrations of different biologic effects of cholecystokinin peptides on pancreatic secretion, underlining the importance of measurement techniques to determine specific forms of peptide hormones involved in physiologic processes; investigations of the details of the central neural pathways involved in the vago-vagal reflex in pancreatic secretion; the demonstration of the essential role for intrapancreatic nerves in mediating meal-induced responses; and identification of a modulatory role for leptin in exocrine pancreatic secretion.

These findings should not only spur further investigations into mechanisms of normal physiology but also provide impetus for application of these findings to studies of pancreatic disorders.