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Related Experiment Videos

Population-based outcomes for pediatric thyroid carcinoma.

Nina L Shapiro1, Neil Bhattacharyya

  • 1Division of Head and Neck Surgery, University of California Los Angeles School of Medicine, Los Angeles, California, USA. nshapiro@ucla.edu

The Laryngoscope
|February 4, 2005
PubMed
Summary

Pediatric thyroid carcinoma, predominantly affecting girls, presents with features similar to adult cases. Despite this, overall survival for children with thyroid cancer is excellent, with a low mortality rate.

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Area of Science:

  • Oncology
  • Pediatric Endocrinology

Background:

  • Thyroid carcinoma in children is rare but requires understanding of its clinical presentation and outcomes.
  • Existing data on pediatric thyroid cancer clinical features and survival is limited.

Purpose of the Study:

  • To define the clinical characteristics of pediatric thyroid carcinoma.
  • To evaluate the clinical outcomes and survival rates for pediatric thyroid carcinoma.

Main Methods:

  • A cross-sectional analysis of the national cancer database was performed.
  • Data from the Surveillance, Epidemiology, and End Results (SEER) database (1988-2000) was used to identify pediatric thyroid carcinoma cases.
  • Kaplan-Meier survival and Cox regression analyses were conducted to assess survival and prognostic factors.

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Main Results:

  • 566 pediatric thyroid carcinoma cases were analyzed, with a mean age of 16.0 years and a female predominance (84.8%).
  • Papillary carcinoma was the most common type, followed by follicular variant and follicular carcinoma.
  • Overall survival was excellent across all histological types, exceeding 145 months, though follicular carcinoma showed slightly poorer survival.

Conclusions:

  • Pediatric thyroid carcinoma predominantly affects females and shares clinical presentation similarities with adult cases.
  • The overall survival for pediatric thyroid carcinoma is excellent, with a low incidence of disease-related death.
  • This study highlights the favorable prognosis of thyroid cancer in the pediatric population.