Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Longitudinal diffusion changes in cerebral hemispheres after MCA infarcts.

Frédérique Buffon1, Nicolas Molko, Dominique Hervé

  • 1Department of Neurology, CHU Lariboisière, Université Paris VII, Paris, France.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|February 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer's disease.

Frontiers in neuroscience·2026
Same author

Risk of Clinical Events in Presymptomatic Familial Cerebral Cavernous Malformations.

European journal of neurology·2026
Same author

Determinants of cerebral microbleed presence and burden in CADASIL.

Cerebral circulation - cognition and behavior·2026
Same author

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL.

Annals of clinical and translational neurology·2026
Same author

Tocotrienol-rich vitamin E complex in CADASIL (T3CAD): a randomised, double-blind, placebo-controlled trial.

EClinicalMedicine·2026
Same author

Singing in the brain.

Japanese journal of radiology·2026

Diffusion tensor imaging reveals microstructural changes in the brain after middle cerebral artery (MCA) infarction. These changes occur both near and far from the infarct, indicating widespread tissue modification over time.

Area of Science:

  • Neuroimaging
  • Neurology
  • Biomedical Engineering

Background:

  • Middle cerebral artery (MCA) infarction causes significant brain damage.
  • Diffusion tensor imaging (DTI) is a powerful tool for assessing brain microstructure.
  • Longitudinal studies are crucial for understanding post-infarction recovery and changes.

Purpose of the Study:

  • To investigate longitudinal microstructural changes after MCA infarction using DTI.
  • To assess both regional and remote effects of MCA infarction on brain tissue.
  • To correlate diffusion changes with infarct progression and brain atrophy.

Main Methods:

  • In vivo Diffusion Tensor Imaging (DTI) was performed on nine patients at multiple time points post-MCA infarction (D7, M1, M3, M6).
  • Analysis included histogram analysis of mean diffusivity (MD) and fractional anisotropy (FA) and voxel-wise statistical parametric mapping (SPM).

Related Experiment Videos

  • Hemispheric and regional analyses were conducted to identify specific patterns of microstructural alteration.

    • Main Results:

    • Ipsilateral hemisphere showed decreased FA and increased MD over time.
    • Remote regions, including the thalamus and pyramidal tract, exhibited significant MD and FA changes.
    • Contralateral hemisphere displayed global atrophy and reduced anisotropy without distinct regional diffusion alterations.

    Conclusions:

    • DTI can detect longitudinal micro- and macrostructural tissue modifications after MCA infarction.
    • Changes are not limited to the infarct core, extending to remote brain regions.
    • Findings highlight the utility of DTI in characterizing the complex spatiotemporal evolution of brain injury post-stroke.