Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MUNC-ing around with insulin action.

David E James1

  • 1Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia. D.james@garvan.org.au

The Journal of Clinical Investigation
|February 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The gut microbiome as an effector of metabolic disease gene variants.

Trends in genetics : TIG·2026
Same author

Integrated analysis of the adipocyte plasma membrane proteome reveals KCC1 and PIT2 as novel insulin-responsive transporters.

The Journal of biological chemistry·2026
Same author

Synteny - a high throughput web tool to streamline causal gene prioritisation and provide insight into protein function.

Scientific reports·2025
Same author

Sex-specific phosphoproteome responses to calorie restriction and insulin in skeletal muscle from older rats.

The journals of gerontology. Series A, Biological sciences and medical sciences·2025
Same author

A consensus guide to preclinical indirect calorimetry experiments.

Nature metabolism·2025
Same author

Genetic variance in the murine defensin locus modulates glucose homeostasis.

The EMBO journal·2025
Same journal

Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

The Journal of clinical investigation·2026
Same journal

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.

The Journal of clinical investigation·2026
Same journal

Ammonia in the crosshairs: microbial targets for metabolic dysfunction-associated steatohepatitis prevention.

The Journal of clinical investigation·2026
Same journal

Molecular mechanisms regulating cGAS/STING activation in health and disease.

The Journal of clinical investigation·2026
Same journal

Cellular plasticity as a therapeutic vulnerability: HNF4α is a key target in lung adenocarcinoma.

The Journal of clinical investigation·2026
Same journal

Nephrin autoimmunity: signal, noise, and a path to clarity.

The Journal of clinical investigation·2026
See all related articles

Understanding insulin resistance in type 2 diabetes is crucial. A new study reveals how Munc18c protein regulates glucose transporter type 4 (GLUT4) movement, offering insights into insulin action and diabetes.

Area of Science:

  • Molecular biology
  • Cellular biology
  • Endocrinology

Background:

  • Insulin resistance, characterized by defective glucose uptake in muscle and fat cells, is central to obesity and type 2 diabetes.
  • Insulin stimulates glucose uptake via the translocation of glucose transporter type 4 (GLUT4) from intracellular vesicles to the cell surface.
  • Regulation of this GLUT4 translocation involves complex interactions between vesicle transport and signal transduction pathways.

Purpose of the Study:

  • To investigate the role of vesicle-trafficking proteins in insulin-stimulated GLUT4 translocation.
  • To elucidate the signaling/trafficking intersection controlling GLUT4 movement.

Main Methods:

  • Utilized genetically modified mice lacking the Munc18c protein, a key player in vesicle trafficking.

Related Experiment Videos

  • Examined the impact of Munc18c deficiency on GLUT4 translocation and insulin signaling.

    • Main Results:

    • Mice lacking Munc18c exhibited impaired insulin-stimulated GLUT4 translocation to the cell surface.
    • This study provides novel insights into the molecular mechanisms governing GLUT4 trafficking in response to insulin.

    Conclusions:

    • Munc18c is essential for the proper regulation of insulin-stimulated glucose uptake.
    • Understanding the Munc18c-mediated pathway offers potential therapeutic targets for type 2 diabetes and obesity.