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Granulomatous interstitial nephritis associated with bone marrow transplantation
Andrew L Schwaderer1, Lois Arend, Marc B Lande
1Division of Pediatric Nephrology, Golisano Children's Hospital at Strong, Department of Pediatrics, University of Rochester, Rochester, New York, USA. andrew_schwaderer@urmc.rochester.edu
Abstract:
We describe two brothers with severe combined immunodeficiency, who presented with systemic granulomatous disease, with granulomatous interstitial nephritis as the main feature, several years following bone marrow transplantation. Neither brother had an apparent drug-induced, infectious disease or autoimmune source for the granulomatous interstitial nephritis. Both patients' renal function improved following treatment with corticosteroids. This report implicates granulomatous interstitial nephritis as a complication of bone marrow transplantation for severe combined immunodeficiency.