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Fibrinogen and other coronary risk factors

Finn Edler Von Eyben1, Ejvind Aae Mouritsen, Jan Holm

  • 1Department of Internal Medicine, Herning Hosital, DK-7400 Herning, Denmark. feve@post5.tele.dk

Metabolism: Clinical and Experimental
|February 4, 2005
PubMed

Insights

Plasma fibrinogen concentration is linked to different coronary risk factors in healthy individuals versus those with a history of myocardial infarction. Understanding these associations is key for cardiovascular disease risk assessment.

Area of Science:

  • Cardiology
  • Biochemistry
  • Epidemiology

Background:

  • Plasma fibrinogen concentration is a marker for cardiovascular risk.
  • Previous studies show varied associations between fibrinogen and coronary risk factors.
  • The influence of complex lipoprotein patterns on this association remains understudied.

Purpose of the Study:

  • To investigate the association between plasma fibrinogen concentration and coronary risk factors.
  • To compare these associations in healthy individuals versus patients with a history of myocardial infarction.

Main Methods:

  • Multiple linear regression analysis was used.
  • Study included 24 healthy controls and 22 myocardial infarction survivors (cases).
  • Data analyzed included family history, social class, lipid profiles, and glucose levels.

Main Results:

  • In controls, family disposition, social class, triglyceride/HDL cholesterol score, and glucose were associated with fibrinogen (R2 = 0.81).
  • In cases, the LDL cholesterol/HDL cholesterol ratio was significantly associated with fibrinogen (R2 = 0.39).
  • Four risk factors explained 75% of fibrinogen variation in healthy subjects; one factor explained 33% in cases.

Conclusions:

  • The pattern of coronary risk factors associated with plasma fibrinogen concentration differs between healthy individuals and myocardial infarction survivors.
  • These findings highlight distinct pathophysiological pathways influencing fibrinogen levels in different cardiovascular health states.

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