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Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
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Use of bone morphogenetic proteins for musculoskeletal applications. An overview

Michael A Mont1, Phillip S Ragland, Bridget Biggins

  • 1Center for Joint Preservation and Reconstruction, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, MD 21215, USA. rhondamont@aol.com

The Journal of Bone and Joint Surgery. American Volume
|February 5, 2005
PubMed
Abstract

No abstract available in PubMed .

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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