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Type 2 diabetes is associated with left ventricular concentric remodeling in hypertensive patients

Kazuo Eguchi1, Kazuomi Kario, Satoshi Hoshide

  • 1Department of Cardiology, Shioya General Hospital, Tochigi, Japan; Department of Cardiology, Jichi Medical School, Tochigi-Ken, Japan. Kazuo-eg@jichi.ac.jp

American Journal of Hypertension
|February 5, 2005
PubMed

Insights

Type 2 diabetes in hypertensive patients is linked to concentric left ventricular (LV) geometry, regardless of blood pressure. This remodeling, characterized by increased LV relative wall thickness, is more prevalent in diabetic individuals.

Area of Science:

  • Cardiology
  • Diabetology
  • Hypertension Research

Background:

  • Left ventricular (LV) geometric remodeling impacts cardiovascular prognosis in hypertensive patients.
  • The influence of diabetes on LV remodeling in hypertensive individuals remains unclear.
  • This study examines how diabetes and ambulatory blood pressure (BP) affect LV geometric remodeling in hypertensive patients with and without diabetes.

Purpose of the Study:

  • To investigate the impact of type 2 diabetes on left ventricular (LV) geometric remodeling in hypertensive patients.
  • To determine the independent association of diabetes and ambulatory blood pressure with LV geometry.
  • To compare LV remodeling patterns between diabetic and nondiabetic hypertensive individuals.

Main Methods:

  • 400 uncomplicated hypertensive patients (161 diabetic, 239 nondiabetic) underwent 24-h ambulatory BP monitoring and echocardiography.
  • Key measurements included 24-h BP levels, LV mass index, and relative wall thickness.
  • Statistical analysis compared LV measurements and identified independent predictors of LV geometry.

Main Results:

  • Diabetic hypertensive patients exhibited significantly higher relative wall thickness (0.50 vs. 0.44, P < .001) and a greater prevalence of concentric LV hypertrophy (39.4% vs. 26.8%, P < .001).
  • Diabetes (OR=2.76) and 24-h systolic BP (OR for 10 mm Hg increase=1.17) were independently associated with increased relative wall thickness.
  • 24-h systolic BP was also independently associated with LV hypertrophy (OR for 10 mm Hg increase=1.32).

Conclusions:

  • Type 2 diabetes is independently associated with concentric left ventricular (LV) geometry in hypertensive patients.
  • This association persists regardless of ambulatory blood pressure levels.
  • Diabetic hypertensive patients demonstrate a distinct pattern of LV remodeling compared to their nondiabetic counterparts.
Abstract

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