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Related Experiment Videos

Dynamic complex formation during the yeast cell cycle.

Ulrik de Lichtenberg1, Lars Juhl Jensen, Søren Brunak

  • 1Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Lyngby, Denmark.

Science (New York, N.Y.)
|February 5, 2005
PubMed
Summary
This summary is machine-generated.

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This study reveals how protein complexes assemble during the yeast cell cycle. Periodically expressed proteins likely control complex activity through just-in-time assembly, regulated by targeted degradation and phosphorylation.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Systems Biology

Background:

  • Understanding protein complex dynamics is crucial for deciphering cellular processes.
  • The yeast cell cycle involves intricate regulatory networks governing protein interactions and expression.

Purpose of the Study:

  • To analyze the temporal dynamics of protein complexes during the yeast cell cycle.
  • To identify novel components and modules within cell cycle-regulated protein networks.

Main Methods:

  • Integration of protein-protein interaction data with gene expression data.
  • Construction of a time-dependent protein interaction network for yeast.
  • Analysis of subunit expression patterns (periodic vs. constitutive).

Main Results:

Related Experiment Videos

  • A time-dependent network revealed cell cycle context for proteins.
  • Most protein complexes comprise both periodically and constitutively expressed subunits.
  • Periodically expressed subunits suggest a 'just-in-time' assembly mechanism for complex regulation.

Conclusions:

  • 'Just-in-time' assembly by periodically expressed subunits likely controls protein complex activity.
  • Targeted degradation and phosphorylation by Cdc28p (Cdk1) specifically regulate periodically expressed proteins.