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Hypoadiponectinemia is associated with ischemic cerebrovascular disease
Miao-Pei Chen1, Jack C-R Tsai, Fu-Mei Chung
1Department of Clinical Research, Pingtung Christian Hospital, Pingtung, Taiwan.
Arteriosclerosis, Thrombosis, and Vascular Biology
|February 5, 2005
Summary
Low adiponectin levels are linked to ischemic cerebrovascular disease (CVD). This study found significantly lower plasma adiponectin in CVD patients, regardless of diabetes status, indicating hypoadiponectinemia is associated with increased CVD risk.
Area of Science:
- Endocrinology
- Cardiovascular Science
- Neurology
Background:
- Adiponectin, an anti-inflammatory peptide, protects against atherosclerosis.
- Hypoadiponectinemia, or low adiponectin levels, is a potential risk factor for cardiovascular diseases.
Purpose of the Study:
- To investigate the presence of hypoadiponectinemia in patients with ischemic cerebrovascular disease (CVD).
- To determine the association between plasma adiponectin levels and the risk of ischemic CVD.
Main Methods:
- A case-control study involving 534 participants (228 with ischemic CVD, 306 without).
- Plasma adiponectin concentrations were measured using an enzyme-linked immunosorbent assay (ELISA).
- Analysis included stratification by diabetes status and assessment of adiponectin levels by quartile and as a continuous variable.
Main Results:
- Patients with ischemic CVD exhibited significantly lower mean plasma adiponectin levels compared to controls.
- This reduction in adiponectin was observed in both diabetic and nondiabetic CVD patients.
- Decreasing adiponectin concentrations were independently associated with a higher risk of CVD.
Conclusions:
- Significantly lower plasma adiponectin levels are present in patients suffering from ischemic cerebrovascular disease.
- Hypoadiponectinemia is a potential biomarker and risk factor for ischemic CVD, even in the presence of type 2 diabetes.