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Use of Enzymatic Biosensors to Quantify Endogenous ATP or H2O2 in the Kidney
Published on: October 12, 2015
[Expectation for Whole PTH assay in the dialysis field]
1Division of Nephrology, San-in Rosai Hospital.
Abstract:
In uremic plasma, it was proven that not only 1-84 PTH but a large C fragment PTH (probably 7-84 PTH) existed considerably and Intact PTH assay measured both PTH molecules. Whole PTH was developed to measure 1-84 PTH exclusively. From our study of the iliac bone biopsy, Whole PTH and Whole PTH/7-84PTH ratio were superior indicator to Intact PTH in diagnosis of adynamic bone disease. Although there is possibility of induction of adynamic bone disease in vitamin D treatment, Whole PTH will serve as a useful monitoring method in order to prevent such risk.
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