Antiphospholipid syndrome: association between laboratory tests and clinical practice

Antiphospholipid antibodies are a wide and heterogeneous group of immunoglobulins, whose presence inpatients with arterial and venous thrombosis, and obstetrical complications defines the antiphospholipid syndrome. We systematically reviewed published articles on this syndrome to investigate the association between thrombosis and the most common antiphospholipid antibodies. Lupus anticoagulants were a clear risk factor for thrombosis, irrespective of the site and type of thrombosis, the presence of systemic lupus erythematosus, and the methods used to detect them. Anticardiolipin and anti 2-glycoprotein I antibodies were possible risk factors of thrombosis, at least in some selected situations. Conversely, the measurement of antiprothrombin antibodies was not helpful to define the patient's risk of thrombosis. These results are mainly due to the still far from optimal standardization of the methods to detect the various antiphospholipid antibodies.