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Do haemostasis activation markers that predict cardiovascular disease exist?

Mojca Stegnar1, Nina Vene, Mojca Bozic

  • 1Department of Angiology, University Medical Centre, Ljubljana, Slovenia. Mojca.Stegnar@trnovo.kclj.si

Pathophysiology of Haemostasis and Thrombosis
|February 5, 2005
PubMed
Summary

Thrombosis is key in cardiovascular disease. D-dimer, a haemostasis marker, consistently predicts cardiovascular events, while other markers need further study.

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Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Hematology

Background:

  • Thrombosis plays a central role in cardiovascular disease (CVD) pathogenesis.
  • Growing interest exists in linking haemostatic variables to CVD risk.
  • Activation products of coagulation and fibrinolysis are promising haemostasis markers.

Purpose of the Study:

  • To investigate the predictive value of haemostasis markers for cardiovascular events.
  • To assess the prognostic utility of specific coagulation and fibrinolysis activation products.

Main Methods:

  • Review of existing epidemiological and clinical studies.
  • Analysis of data on markers including prothrombin fragment 1+2 (F1+2), fibrinopeptide A (FPA), soluble fibrin, thrombin-antithrombin (TAT) complexes, plasmin-antiplasmin (PAP) complexes, and D-dimer.

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Main Results:

  • D-dimer is extensively studied and shows substantial evidence as a strong, consistent predictor of cardiovascular events in both general and patient populations.
  • Data on other haemostasis markers (F1+2, FPA, soluble fibrin, TAT, PAP) are less abundant and yield more controversial results regarding their prognostic value.

Conclusions:

  • D-dimer is a validated prognostic marker for cardiovascular events.
  • The prognostic value of other haemostasis activation products requires further definition through future research.