Related Experiment Video
Updated: Aug 19, 2026

Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model
Published on: April 19, 2024
Thrombin activatable fibrinolysis inhibitor (TAFI) at the interface between coagulation and fibrinolysis
Bonno N Bouma1, Laurent O Mosnier
1Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA. bouma@scripps.edu
Abstract:
The thrombin-catalysed conversion of plasma fibrinogen into fibrin and the development of an insoluble fibrin clot are the final steps of the coagulation cascade during haemostasis. A delicate balance between coagulation and fibrinolysis determines the stability of the fibrin clot. Thrombin Activatable Fibrinolysis Inhibitor (TAFI) plays an important role in this process. TAFI is activated by thrombin and protects the fibrin clot against lysis. The role of TAFI in bleeding and thrombotic disorders is discussed as well as its novel emerging role in wound healing and inflammation.
Related Concept Videos
Clot Retraction and Fibrinolysis
Venous Thrombosis III: Interprofessional Care
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Transient Ischemic Attack l: Introduction
Venous Thrombosis I: Introduction
Intracellular Signaling Affects Focal Adhesions
Some...

