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Related Experiment Videos

[A persistent ulceration after a fortuitous BCG revaccination].

E Cuchet1, I Templier, J-P Brion

  • 1Département pluridisciplinaire de Médecine, Secteur de Dermatologie, CHU Michallon, 38043 Grenoble.

Annales De Dermatologie Et De Venereologie
|February 5, 2005
PubMed
Summary

A rare complication of Bacillus Calmette-Guérin (BCG) revaccination, a cutaneous ulceration caused by Mycobacterium bovis infection, is presented. This case highlights potential infectious or immune-mediated adverse reactions to BCG revaccination.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Dermatology

Background:

  • Bacillus Calmette-Guérin (BCG) vaccination is widely used, with known side effects ranging from non-specific reactions to those directly caused by Mycobacterium bovis infection.
  • Complications arising from BCG revaccination are less frequently documented compared to primary vaccination.

Observation:

  • A 17-year-old male developed a slow-progressing cutaneous ulceration on his left deltoid area after an incidental BCG revaccination.
  • Swab cultures of the ulcer exudate identified Mycobacterium bovis, though Ziehl staining was negative.
  • The ulcer healed within four months following treatment with isoniazid.

Findings:

  • The case suggests that BCG revaccination can lead to adverse reactions, potentially through infectious or immune-mediated mechanisms.

Related Experiment Videos

  • Possible mechanisms include direct infection by Mycobacterium bovis or an immune response such as Arthus-type phenomenon or type IV hypersensitivity.

    • Implications:

    • Although BCG revaccination is being phased out in some regions, accidental occurrences can still lead to complications.
    • This case underscores the importance of recognizing and managing rare adverse reactions to BCG vaccination, even in revaccination scenarios.