Related Experiment Videos
Vocal fold augmentation by autologous fat injection with lipostructure procedure
Giovanna Cantarella1, Riccardo F Mazzola, Elena Domenichini
1Department of Otolaryngology, University of Milan and Ospedale Maggiore di Milano, IRCCS, Italy. giovanna.cantarella@policlinico.mi.it
Summary
Coleman's lipostructure technique effectively rehabilitates voice in patients with glottic incompetence. This fat grafting method shows sustained voice quality improvement, particularly for paralytic dysphonia.
Area of Science:
- Otolaryngology
- Regenerative Medicine
- Acoustic Science
Background:
- Autologous fat is an ideal vocal fold augmentation material due to biocompatibility.
- Fat reabsorption remains a significant challenge for long-term vocal fold augmentation success.
- Glottic incompetence can lead to breathy dysphonia, impacting voice quality.
Purpose of the Study:
- To prospectively evaluate Coleman's lipostructure technique for treating glottic incompetence.
- To assess the efficacy of vocal fold lipoinjection in voice rehabilitation.
- To determine the long-term stability of voice improvement after fat grafting.
Main Methods:
- Prospective study involving 14 patients with glottic incompetence.
- Coleman's lipostructure technique: fat harvested, centrifuged, and injected into the vocalis muscle.
- Pre- and postoperative assessments included videolaryngostroboscopy, MPT, GRBAS, and VHI.
Main Results:
- Significant voice quality improvement observed post-lipoinjection, sustained over a mean of 10.6 months.
- Objective and subjective measures (GRBAS, MPT, VHI) confirmed voice enhancement (P < 0.005).
- Optimal outcomes were noted in patients with paralytic dysphonia.
Conclusions:
- Coleman's lipostructure is a valuable and effective technique for voice rehabilitation in glottic incompetence.
- Vocal fold lipoinjection offers a promising solution for improving voice quality and function.
- The technique demonstrates sustained efficacy, particularly in cases of paralytic dysphonia.