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Acute myocardial infarction in sickle cell disease: a possible complication of hydroxyurea treatment

André Fattori1, Robenílson Almeida de Souza, Sara Terezinha Olalla Saad

  • 1Hemocentro da UNICAMP, Campinas, Brazil. afattori@unicamp.br

The Hematology Journal : the Official Journal of the European Haematology Association
|February 5, 2005
PubMed

We describe a 28-year-old man treated with hydroxyurea for sickle cell anemia, who was admitted to the University Hospital with an acute myocardial infarction. The patient had evolved high hematocrit values during his long-term hydroxyurea treatment, suggesting a correlation between a possible increment in blood viscosity and the coronary occlusion without previous lesions. Indeed, several studies associate vasocclusive episodes and severe clinical course with high viscosity. Although hydroxyurea is considered an effective therapeutic option for these patients, care should be taken to monitor hematocrit levels and possible complications. Hematocrit and hemoglobin values of above 30% and 10.5 g/dl in SS patients on hydroxyurea therapy should be avoided or closely monitored.

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