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Updated: Aug 19, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
[Pathogenesis of autoimmune hepatitis]
Nadia Maamouri1, Hager Ouerghi, Néziha Belkahla
1Service de Gastro.B, La Rabta.
Objectives:
The aim of the study was to review the pathogenic mechanisms of auto-immune hepatitis.
Methods:
The study was based on a review of all relevant articles from literature on the mechanisms of auto-immunity in auto-immune hepatitis.
Results:
The precise mechanisms through which liver damage occurs are not fully understood. Auto-immune hepatitis seems to be a consequence of auto-antigen exposure, genetic predisposition and defective immuregulatory mechanisms. Auto-antigen is presented by class II molecules of the major histocompatibility complex. Cytokines and non specific auto-immune promotors modulate immune reactivity. Cell-mediated and antibody-dependent forms of cytotoxicity are probably interactive pathogenic mechanisms.
Conclusion:
Disturbance in the tight balance between auto-aggression and self-tolerance, affected by several internal and external factors are likely in auto-immune hepatitis.
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