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Marked decrease in the levels of two inflammatory markers, hs-C-reactive protein and fibrinogen in patients with

E Dósa1, S Rugonfalvi-Kiss, Z Prohászka

  • 1Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|February 8, 2005
PubMed

Insights

Eversion endarterectomy significantly reduces levels of plasma fibrinogen and high-sensitivity C-reactive protein (hs-CRP) in patients with severe carotid stenosis. This reduction indicates decreased inflammation following atherosclerotic plaque removal.

Area of Science:

  • Vascular Surgery
  • Cardiovascular Medicine
  • Inflammation Biomarkers

Background:

  • Severe carotid stenosis poses a significant risk for stroke.
  • Acute phase proteins like fibrinogen and hs-CRP are indicators of inflammation.
  • Eversion endarterectomy is a surgical procedure to remove plaque from carotid arteries.

Purpose of the Study:

  • To investigate the impact of eversion endarterectomy on plasma fibrinogen and serum hs-CRP levels.
  • To assess changes in inflammatory markers post-carotid endarterectomy.

Main Methods:

  • A cohort of 117 patients with severe carotid stenosis undergoing eversion endarterectomy was studied.
  • Plasma fibrinogen and serum hs-CRP levels were measured pre-operatively and at two post-operative time points (median 5.7 weeks and 13.8 months).

Main Results:

  • A statistically significant decrease in both plasma fibrinogen and serum hs-CRP concentrations was observed post-surgery (p < 0.0001).
  • The reduction in hs-CRP was most pronounced in patients with initially high baseline levels.

Conclusions:

  • Eversion endarterectomy effectively reduces the production of acute phase proteins, suggesting a decrease in systemic inflammation.
  • The removal of atherosclerotic plaques likely diminishes the inflammatory burden associated with severe carotid stenosis.
Abstract

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