Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treatment options for bipolar depression.

Charles L Bowden1

  • 1Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. bowdenc@uthscsa.edu

The Journal of Clinical Psychiatry
|February 8, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KIOS: A smartphone app for self-monitoring for patients with bipolar disorder.

Bipolar disorders·2023
Same author

Childhood trauma and treatment outcomes during mood-stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder.

Acta psychiatrica Scandinavica·2022
Same author

Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes.

The Australian and New Zealand journal of psychiatry·2022
Same author

Cardiometabolic risk markers during mood-stabilizing treatment: Correlation with drug-specific effects, depressive symptoms and treatment response.

Journal of affective disorders·2021
Same author

Response and remission rates during 24 weeks of mood-stabilizing treatment for bipolar depression depending on early non-response.

Psychiatry research·2021
Same author

Development of a Patient-Centered Software System to Facilitate Effective Management of Bipolar Disorder.

Psychopharmacology bulletin·2021

Bipolar disorder is often misdiagnosed as major depressive disorder. Effective treatments for bipolar depression include medication combinations and psychoeducation, which may reduce relapse rates.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Bipolar disorder (BD) is frequently misdiagnosed as major depressive disorder (MDD) due to overlapping depressive symptoms.
  • Treatment-resistant depression in BD can indicate a more severe illness course, but underlying factors remain unclear.
  • Limited prospective data exist on antidepressant efficacy for BD depression, with varying results.

Purpose of the Study:

  • To review current understanding of bipolar depression treatment.
  • To evaluate the effectiveness and risks of antidepressants in bipolar depression.
  • To discuss newer treatment options and adjunctive therapies like psychoeducation.

Main Methods:

  • Review of existing literature on bipolar depression treatment.

Related Experiment Videos

  • Analysis of data regarding antidepressant efficacy and mania induction rates.
  • Examination of newer FDA-approved treatments and psychoeducational interventions.

    • Main Results:

    • Antidepressant effectiveness data for bipolar depression are inconsistent.
    • Selective serotonin reuptake inhibitors (SSRIs) and lamotrigine show mania induction rates similar to placebo.
    • Longer antidepressant treatment (≥6 months) may help prevent relapse.
    • Combination olanzapine/fluoxetine and lamotrigine are FDA-approved for specific BD depressive/maintenance phases.
    • Psychoeducation combined with medication may lower relapse rates compared to medication alone.

    Conclusions:

    • Accurate diagnosis of bipolar disorder is crucial to avoid misdiagnosis as MDD.
    • Careful consideration of antidepressant use in BD is necessary due to variable efficacy and potential for mania induction.
    • Novel pharmacotherapies and psychoeducation represent promising strategies for managing bipolar depression.