Related Experiment Video
Updated: Aug 19, 2026
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Subclinical hypothyroidism caused by a mutation of the thyrotropin receptor gene
Keiko Shibayama1, Yoshihide Ohyama, Akira Hishinuma
1Department of Pediatrics, Kitasato University School of Medicine, Kanagawa 228-8555, Japan. ki@med.kitasato-u.ac.jp
Abstract
No abstract available in PubMed .
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Overview
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...