Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokines and major depression.

Olga J G Schiepers1, Marieke C Wichers, Michael Maes

  • 1Department of Psychiatry and Neuropsychology, Maastricht University, P.O. BOX 616, 6200 MD Maastricht, The Netherlands.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|February 8, 2005
PubMed
Summary

Proinflammatory cytokines, like IL-1 and TNF-alpha, may drive depression by affecting brain function and neurotransmitters. Research explores their role in major depression, linking inflammation to depressive symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Environmental, Neuro-immune, and Neuro-oxidative Stress Interactions in Chronic Fatigue Syndrome.

Molecular neurobiology·2020
Same author

Lowered Antioxidant Defenses and Increased Oxidative Toxicity Are Hallmarks of Deficit Schizophrenia: a Nomothetic Network Psychiatry Approach.

Molecular neurobiology·2020
Same author

The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach.

Life sciences·2020
Same author

Maternal Immune Activation Causes Schizophrenia-like Behaviors in the Offspring through Activation of Immune-Inflammatory, Oxidative and Apoptotic Pathways, and Lowered Antioxidant Defenses and Neuroprotection.

Molecular neurobiology·2020
Same author

Efficacy, cost-utility and physiological effects of Acceptance and Commitment Therapy (ACT) and Behavioural Activation Treatment for Depression (BATD) in patients with chronic low back pain and depression: study protocol of a randomised, controlled trial including mobile-technology-based ecological momentary assessment (IMPACT study).

BMJ open·2020
Same author

The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression.

Molecular neurobiology·2020

Area of Science:

  • Psychoneuroimmunology
  • Neuroscience
  • Psychiatry

Background:

  • Evidence suggests bidirectional communication between nervous, endocrine, and immune systems.
  • The immune system's role in psychiatric disorders is gaining attention.
  • Proinflammatory cytokines are implicated in the pathophysiology of major depression.

Purpose of the Study:

  • To review the role of proinflammatory cytokines in the aetiology and pathophysiology of major depression.
  • To discuss the 'cytokine hypothesis of depression'.

Main Methods:

  • Review of existing literature on cytokines and depression.
  • Examination of findings linking inflammatory conditions to depression.
  • Analysis of cytokine administration effects in humans and animals.

Related Experiment Videos

Main Results:

  • Proinflammatory cytokines (IL-1, TNF-alpha, IFN-gamma) may act as neuromodulators in depression.
  • Conditions with chronic inflammation (e.g., rheumatoid arthritis) are associated with depression.
  • Cytokine administration can induce depressive symptoms and sickness behavior.
  • Cytokines may cause hypothalamic-pituitary-adrenal (HPA) axis hyperactivity.
  • Cytokines might reduce serotonin by activating indoleamine-2,3-dioxygenase (IDO), lowering tryptophan.

Conclusions:

  • Proinflammatory cytokines may explain key features of depression.
  • The causal role of cytokines in depression requires further investigation.
  • Cytokines could be central mediators or epiphenomena in depressive disorders.