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Updated: Aug 19, 2026

Proximity Ligand Assay to Localize Proteins in DNA Damage Sites
Published on: August 2, 2024
DNA repair: the importance of phosphorylating histone H2AX
Noel F Lowndes1, Geraldine W-L Toh
1Genome Stability Laboratory, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.
Abstract:
How phosphorylated histone H2AX, known as gamma-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that gamma-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together.
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