[Fragile X syndrome and very early onset schizophrenia: a female case study]
V Vantalon1, V Briard-Luginbuhl, M C Mouren
1Service de psychopathologie de l'enfant et de l'adolescent, hôpital Robert-Debré, assistance publique-hôpitaux de Paris, 48 boulevard Sérurier, 75019 Paris, France. valerie.vantalon@rdb.ap-hop-paris.fr
Abstract:
Genotype-phenotype relationship studies for psychiatric disorders in females carrying fragile X syndrome full mutation and premutation underline association with schizo-affective disorders. In female children with X fragile full mutation, only behavioural symptoms and no standardised psychiatric disorders have been systematically explored. Therefore, we report the case of a nine-year-old girl carrying the fragile X syndrome full mutation with a comorbid childhood onset schizophrenia (COS), and of her mother carrying the fragile X syndrome premutation and a comorbid schizotypal personality disorder. The impact of these associations is discussed regarding the recent literature in chromosome anomalies in COS.
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