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How to write up a hypothesis: the good, the bad and the ugly
Abstract:
Medical Hypotheses exists to give ideas and speculations in medicine a fair hearing. Doing this is not easy. Most conventional journals would regard some of what is published here as questionable, most referees would reject it as 'unproven'. We have more liberal standards, for reasons we have presented before. But we still require 'good' science -- logical argument that is supported by fact and comes to interesting, even useful, conclusions. Alas, not everything received comes close to even this liberal standard. Since I joined the Editorial Board I have read about 130 submissions to Medical Hypotheses. They range from exciting and insightful papers that might be substantial advances in their field, to complete rubbish. I want to lay out what I believe to be the essence of the former so as to avoid having to read so much of the latter.
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What is a Hypothesis?
Null and Alternative Hypotheses
The null hypothesis, denoted by H0 is a statement of no difference between the variables—they are not related. This can often be considered the status quo. As a result if you cannot accept the null, it requires some action.
The alternative hypothesis, denoted by H1 or Ha, is a claim about the population that is...
Types of Hypothesis Testing
When the null and alternative hypotheses are stated, it is observed that the null hypothesis is a neutral statement against which the alternative hypothesis is tested. The alternative hypothesis is a claim that instead has a certain direction. If the null hypothesis claims that p = 0.5, the alternative hypothesis would be an opposing statement to this and can be put either p > 0.5, p < 0.5, or p ≠ 0.5.
Hypothesis: Accept or Fail to Reject?
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null hypothesis and 'fail to...
Statistical Hypothesis Testing
Statistical significance measures the probability that an observed result occurred by chance. If this probability, known as...
Accuracy and Errors in Hypothesis Testing
In hypothesis testing, the probability of making a Type I error, denoted as α, is commonly set at 0.05. This significance level indicates a 5% chance...