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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Case Studies01:22

Case Studies

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There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
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Brain Waves01:23

Brain Waves

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Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
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Related Experiment Video

Updated: Feb 6, 2026

A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells
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Brain stem glioma: two case studies.

Ruth K Rosenblum1

  • 1Lucile Salter Packard Children's Hospital, Palo Alto, California 94305-5824, USA. rrosenblum@stanfordmed.org

Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses
|February 8, 2005
PubMed
Summary

Families navigate brain stem glioma diagnoses differently. This study presents two cases, highlighting individualized multidisciplinary care and the profound impact on family experiences during treatment and end-of-life care.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Palliative Care

Background:

  • Brain stem glioma presents a dismal prognosis for school-aged children.
  • Family coping mechanisms and support systems vary significantly.
  • Individualized care is crucial throughout diagnosis, treatment, and end-of-life stages.

Observation:

  • Presents case studies of two school-aged girls diagnosed with brain stem glioma.
  • Details the individualized, multidisciplinary team response tailored to each family's needs.
  • Notes an unusual chronological convergence of the two families as both children neared death.

Findings:

  • Each family's journey with brain stem glioma was unique, requiring distinct approaches to care.
  • The multidisciplinary team provided tailored support across all phases of illness.

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  • The shared experience created an intense, challenging, and educational journey for families and the care team.

    • Implications:

    • Highlights the importance of personalized, compassionate care in pediatric neuro-oncology.
    • Emphasizes the profound impact of a brain stem glioma diagnosis on the entire family unit.
    • Suggests the need for continued research into family-centered support models for rare childhood cancers.