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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Lipoprotein-a: a laboratory tool for clinical categorization of CVD

M M Hoque1, P Sultana, M I Arslan

  • 1BSMMU, Dhaka.

Mymensingh Medical Journal : MMJ
|February 8, 2005
PubMed

Insights

Elevated Lipoprotein(a) [LP(a)] levels are associated with cerebrovascular disease (CVD). Higher LP(a) concentrations may help differentiate ischemic CVD from hemorrhagic CVD.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Neurology

Background:

  • Lipoprotein(a) [LP(a)] is implicated in cardiovascular disease.
  • Distinguishing between ischemic and hemorrhagic cerebrovascular disease (CVD) is clinically important.

Purpose of the Study:

  • To evaluate the association between LP(a) and CVD.
  • To assess LP(a) as a differentiating marker between ischemic CVD (ICVD) and hemorrhagic CVD (HCVD).

Main Methods:

  • A case-control study involving 150 subjects (120 CVD cases, 30 healthy controls).
  • Exclusion criteria: smokers, alcoholics, and individuals with DM, renal, thyroid, or liver disease.
  • Serum LP(a) concentrations were measured in fasting blood samples.

Main Results:

  • Mean serum LP(a) levels were significantly higher in both HCVD (31.9 ± 15.6 mg/dl) and ICVD (44.8 ± 24.0 mg/dl) cases compared to controls (17.6 ± 7.4 mg/dl).
  • ICVD cases exhibited significantly higher LP(a) concentrations than HCVD cases.
  • LP(a)'s athero-thrombo-embolic potential likely contributes to its association with CVD, particularly ICVD.

Conclusions:

  • Serum LP(a) concentration is significantly associated with CVD.
  • LP(a) may serve as a promising laboratory marker for differentiating ICVD from HCVD.

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