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[Natural products with antimycotic activity]
A C Mesa Arango1, J G Bueno Sánchez, L A Betancur Galvis
1Grupo Infección y Cancer, Linea de Bioactividad de Productos Naturales, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. amesa@medicina.udea.edu.co
Summary
The rise in fungal infections and antifungal resistance necessitates novel treatments. Natural sources like plants and microorganisms offer promising antifungal compounds as alternatives to conventional drugs.
Area of Science:
- Microbiology
- Pharmacology
- Natural Product Chemistry
Context:
- Global increase in fungal infection incidence.
- Growing resistance to conventional antifungal medications.
- Need for novel antifungal agents with improved efficacy and safety profiles.
Purpose:
- To review natural sources of antimycotic compounds.
- To highlight molecules with antifungal activity from diverse natural origins.
- To explore alternatives for developing new antifungal drugs.
Summary:
- Natural sources, including plants, insects, and microorganisms, yield compounds with significant antifungal properties.
- These natural molecules show activity against clinically important fungal species.
- They represent a viable alternative for developing new antifungals with fewer side effects, broader action, and lower costs.
Impact:
- Facilitates the discovery and development of new antifungal therapies.
- Provides a foundation for research into natural product-based antimycotics.
- Offers potential solutions to combatting antifungal resistance and improving patient outcomes.